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Chemical structure of PROTAC α-synuclein degrader 3

GC75201

PROTAC α-synuclein degrader 3

Also known as (2S,4R)-1-[(2S)-3,3-dimethyl-2-[[2-[2-[2-[2-[2-[2-[2-[[2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]butanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

PROTAC α-synuclein degrader 3 (compound 5) is a potent and selective PROTAC α-synuclein degrader

ChemicalCAS2412273-77-7MW1005.25FormulaC51H68N6O11S2
CAS number
2412273-77-7
Molecular weight
1005.25
Formula
C51H68N6O11S2
Solubility
DMSO： 100 mg/mL (99·48 mM; Need ultrasonic)
InChIKey
QABBEPRQMRXJDK-JNKORLQQSA-N
Catalogue number
GC75201
Brand
GLPBIO
Computed properties PubChem CID 146458535 · XLogP 5.6 · TPSA 258 Ų · H-bond donors 4
XLogP
5.6
TPSA
258 Ų
H-bond donors
4
H-bond acceptors
16
Rotatable bonds
30
Heavy atoms
70

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCOCCOCCOCCOC4=CC5=C(C=C4)N=C(S5)C6=CC=C(C=C6)NC)O

Computed descriptors from PubChem (CID 146458535), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.