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Chemical structure of MTX-531

GC74012

MTX-531

Also known as N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]quinazolin-6-yl]-3-pyridinyl]methanesulfonamide

MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14·7 nM) and PI3K (with IC50 values of 6·4, 233, 8·3, and 1·1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects

ChemicalCAS2791417-66-6MW453.94FormulaC22H20ClN5O2S
CAS number
2791417-66-6
Molecular weight
453.94
Formula
C22H20ClN5O2S
Solubility
DMSO ： 100 mg/mL (220·29 mM; Need ultrasonic)
InChIKey
LPJIZDSOUGHTNB-CQSZACIVSA-N
Catalogue number
GC74012
Brand
GLPBIO
Computed properties PubChem CID 164809124 · XLogP 4.2 · TPSA 105 Ų · H-bond donors 2
XLogP
4.2
TPSA
105 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
31

SMILES C[C@H](C1=CC=CC=C1)NC2=NC=NC3=C2C=C(C=C3)C4=CC(=C(N=C4)Cl)NS(=O)(=O)C

Computed descriptors from PubChem (CID 164809124), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
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