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Chemical structure of VU0448088

GC74010

VU0448088

Also known as 3-amino-5-chloro-4,6-dimethyl-N-(pyridin-4-ylmethyl)thieno[2,3-b]pyridine-2-carboxamide

VU0448088 (ML253) is a potent and cross the blood-brain barrier tricyclic muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator with EC50 of 56, 176 nM for human and rat, respectively

ChemicalCAS1417616-42-2MW346.83FormulaC16H15ClN4OS
CAS number
1417616-42-2
Molecular weight
346.83
Formula
C16H15ClN4OS
Solubility
DMSO ： 5 mg/mL (14·42 mM; Need ultrasonic)
InChIKey
XNCQMFVABACABG-UHFFFAOYSA-N
Catalogue number
GC74010
Brand
GLPBIO
Computed properties PubChem CID 53382523 · XLogP 3.5 · TPSA 109 Ų · H-bond donors 2
XLogP
3.5
TPSA
109 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
23

SMILES CC1=C2C(=C(SC2=NC(=C1Cl)C)C(=O)NCC3=CC=NC=C3)N

Computed descriptors from PubChem (CID 53382523), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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