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Chemical structure of PHTPP-1304

GC73960

PHTPP-1304

Also known as (2R)-1-[2-[2-[2-[4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenoxy]ethoxy]ethoxy]ethylamino]-3-[4-phenylmethoxy-3-(3-phenylpropoxy)phenoxy]propan-2-ol

PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization and degradation of estrogen receptor ERβ (DC50:~2 nM, HEK293T)

ChemicalCAS2410081-60-4MW944.96FormulaC51H50F6N4O7
CAS number
2410081-60-4
Molecular weight
944.96
Formula
C51H50F6N4O7
Solubility
DMSO ： 110 mg/mL (116·41 mM; Need ultrasonic)
InChIKey
RFLBGKJLIDOOAA-RRHRGVEJSA-N
Catalogue number
GC73960
Brand
GLPBIO
Computed properties PubChem CID 153397130 · XLogP 9.5 · TPSA 118 Ų · H-bond donors 2
XLogP
9.5
TPSA
118 Ų
H-bond donors
2
H-bond acceptors
16
Rotatable bonds
25
Heavy atoms
68

SMILES C1=CC=C(C=C1)CCCOC2=C(C=CC(=C2)OC[C@@H](CNCCOCCOCCOC3=CC=C(C=C3)C4=C5N=C(C=C(N5N=C4C6=CC=CC=C6)C(F)(F)F)C(F)(F)F)O)OCC7=CC=CC=C7

Computed descriptors from PubChem (CID 153397130), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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