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Chemical structure of PHTPP

GC11863

PHTPP

Also known as 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

PHTPP is a selective ERβ full antagonist with 36-fold selectivity for ERβ over ERα· PHTPP can selectively antagonize the ligand binding and transcriptional functions of ERβ, blocking its inhibitory effect on tumor cells, thereby promoting cell proliferation· PHTPP was used to verify ERβ function

ChemicalCAS805239-56-9MW423.31FormulaC20H11F6N3O
CAS number
805239-56-9
Molecular weight
423.31
Formula
C20H11F6N3O
Solubility
≤30mg/ml in ethanol;50mg/ml in DMSO
InChIKey
AEZPAUSGTAHLOQ-UHFFFAOYSA-N
Catalogue number
GC11863
Brand
GLPBIO
Computed properties PubChem CID 11201035 · XLogP 5.1 · TPSA 50.4 Ų · H-bond donors 1
XLogP
5.1
TPSA
50.4 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
2
Heavy atoms
30

SMILES C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F

Computed descriptors from PubChem (CID 11201035), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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