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Chemical structure of WRN inhibitor 8

GC73907

WRN inhibitor 8

Also known as 2-[cyclopropyl(difluoro)methyl]-N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-4-phenoxypyrimidine-5-carboxamide

WRN inhibitor 8 (Example 224) is a WRN helicase inhibitor with IC50 value of 48 nM

ChemicalCAS3026502-95-1MW463.5FormulaC22H23F2N3O4S
CAS number
3026502-95-1
Molecular weight
463.5
Formula
C22H23F2N3O4S
Solubility
DMSO ： 125 mg/mL (269·69 mM; Need ultrasonic)
InChIKey
SGERSEZXZIVUEY-IENJSVCTSA-N
Catalogue number
GC73907
Brand
GLPBIO
Computed properties PubChem CID 170718255 · XLogP 2.9 · TPSA 107 Ų · H-bond donors 1
XLogP
2.9
TPSA
107 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
9
Heavy atoms
32

SMILES CS(=O)(=O)/C=C/[C@H](C1CC1)NC(=O)C2=CN=C(N=C2OC3=CC=CC=C3)C(C4CC4)(F)F

Computed descriptors from PubChem (CID 170718255), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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