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Chemical structure of TDP-43 degrader-1

GC73851

TDP-43 degrader-1

Also known as 7-methoxy-1-[(E)-2-(5-methoxy-1-methylpyrrolo[2,3-b]pyridin-3-yl)ethenyl]-6-phenylmethoxy-1,2,3,4-tetrahydroisoquinoline

TDP-43 degrader-1 (example 3) reduces the TDP-43 aggregation that can be in the research of Amyotrophic lateral sclerosis and Alzheimer's disease

ChemicalCAS2902692-25-3MW455.55FormulaC28H29N3O3
CAS number
2902692-25-3
Molecular weight
455.55
Formula
C28H29N3O3
InChIKey
RKKQXGNMFVKLDL-MDZDMXLPSA-N
Catalogue number
GC73851
Brand
GLPBIO
Computed properties PubChem CID 167346038 · XLogP 4.4 · TPSA 57.5 Ų · H-bond donors 1
XLogP
4.4
TPSA
57.5 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
7
Heavy atoms
34

SMILES CN1C=C(C2=C1N=CC(=C2)OC)/C=C/C3C4=CC(=C(C=C4CCN3)OCC5=CC=CC=C5)OC

Computed descriptors from PubChem (CID 167346038), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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