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Chemical structure of NUCC-0226272

GC73764

NUCC-0226272

Also known as (2S,4R)-1-[(2S)-2-[[11-[4-[[4-[3-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methylcarbamoyl]-5-[ethyl(oxan-4-yl)amino]-4-methylphenyl]phenyl]methyl]piperazin-1-yl]-11-oxoundecanoyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

NUCC-0226272 is a potent PROTAC that targets EZH2 for degradation

ChemicalCAS3004503-12-9MW1182.56FormulaC67H91N9O8S
CAS number
3004503-12-9
Molecular weight
1182.56
Formula
C67H91N9O8S
Solubility
DMSO ： ≥ 140 mg/mL (118·39 mM)
InChIKey
GQULETMWOLCBGK-MUSRFAHESA-N
Catalogue number
GC73764
Brand
GLPBIO
Computed properties PubChem CID 171038189 · XLogP 9.2 · TPSA 234 Ų · H-bond donors 5
XLogP
9.2
TPSA
234 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
26
Heavy atoms
85

SMILES CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCN(CC5)C(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@@H](C[C@H]6C(=O)NCC7=CC=C(C=C7)C8=C(N=CS8)C)O)C(C)(C)C

Computed descriptors from PubChem (CID 171038189), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.