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Chemical structure of JAK3-IN-14

GC73600

JAK3-IN-14

Also known as 5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one

JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively

ChemicalCAS454234-24-3MW287.32FormulaC18H13N3O
CAS number
454234-24-3
Molecular weight
287.32
Formula
C18H13N3O
Solubility
DMSO ： 125 mg/mL (435·05 mM; Need ultrasonic)
InChIKey
IQNTXIMXKCURDC-UHFFFAOYSA-N
Catalogue number
GC73600
Brand
GLPBIO
Computed properties PubChem CID 24906279 · XLogP 2.3 · TPSA 57.8 Ų · H-bond donors 2
XLogP
2.3
TPSA
57.8 Ų
H-bond donors
2
H-bond acceptors
2
Rotatable bonds
2
Heavy atoms
22

SMILES C1=CC(=CN=C1)C2=CC3=C(C=C2)NC(=O)C3=CC4=CC=CN4

Computed descriptors from PubChem (CID 24906279), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.