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Chemical structure of PD-L1-IN-3

GC73546

PD-L1-IN-3

Also known as 2-[[4-(aminomethyl)phenyl]methoxy]-4-(4-fluorophenyl)thiophene-3-carbonitrile;hydrochloride

PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4·97nM and 2·70 μM for inhibit PD-L1 and Jurkat T cells, respectively

ChemicalCAS2953044-29-4MW374.86FormulaC19H16ClFN2OS
CAS number
2953044-29-4
Molecular weight
374.86
Formula
C19H16ClFN2OS
Solubility
DMSO ： 125 mg/mL (333·46 mM; Need ultrasonic)
InChIKey
ARPPMPJCLFWQEY-UHFFFAOYSA-N
Catalogue number
GC73546
Brand
GLPBIO
Computed properties PubChem CID 168510313 · TPSA 87.3 Ų · H-bond donors 2 · H-bond acceptors 5
TPSA
87.3 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
25

SMILES C1=CC(=CC=C1CN)COC2=C(C(=CS2)C3=CC=C(C=C3)F)C#N.Cl

Computed descriptors from PubChem (CID 168510313), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.