Loading...
Chemical structure of PD-L1-IN-1

GC63984

PD-L1-IN-1

Also known as N-[2-[[4-[(2-methyl-3-phenylphenyl)methoxy]-1,3,5-triazin-2-yl]amino]ethyl]acetamide

PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM· PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter· PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells

ChemicalCAS2767424-13-3MW377.44FormulaC21H23N5O2
CAS number
2767424-13-3
Molecular weight
377.44
Formula
C21H23N5O2
Solubility
DMSO ： 125 mg/mL (331·18 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LGWZTWZGNYPECF-UHFFFAOYSA-N
Catalogue number
GC63984
Brand
GLPBIO
Computed properties PubChem CID 163323831 · XLogP 3.4 · TPSA 89 Ų · H-bond donors 2
XLogP
3.4
TPSA
89 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
8
Heavy atoms
28

SMILES CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC=NC(=N3)NCCNC(=O)C

Computed descriptors from PubChem (CID 163323831), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.