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Chemical structure of PROTAC Her3 Degrader-8

GC73489

PROTAC Her3 Degrader-8

Also known as (2R,4S)-1-[(2R)-2-[[2-[4-[4-amino-3-[4-phenoxy-3-(prop-2-enoylamino)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

PROTAC Her3 Degrader-8 (Compound PP2) is a PROTAC that can degrade Her3 protein in vitro and cell experiments, and can be used to study diseases regulated by HER family proteins

ChemicalCAS2103331-95-7MW926.1FormulaC49H55N11O6S
CAS number
2103331-95-7
Molecular weight
926.1
Formula
C49H55N11O6S
Solubility
DMSO ： 100 mg/mL (107·98 mM; Need ultrasonic)
InChIKey
OVCGHYOSRVGRMJ-RQWACUIYSA-N
Catalogue number
GC73489
Brand
GLPBIO
Computed properties PubChem CID 148838681 · XLogP 5.4 · TPSA 251 Ų · H-bond donors 5
XLogP
5.4
TPSA
251 Ų
H-bond donors
5
H-bond acceptors
13
Rotatable bonds
15
Heavy atoms
67

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@H]3C[C@@H](CN3C(=O)[C@@H](C(C)(C)C)NC(=O)CN4CCC(CC4)N5C6=NC=NC(=C6C(=N5)C7=CC(=C(C=C7)OC8=CC=CC=C8)NC(=O)C=C)N)O

Computed descriptors from PubChem (CID 148838681), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.