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Chemical structure of PF-07284892

GC73482

PF-07284892

Also known as (1S)-1'-[6-[(2-amino-3-chloro-4-pyridinyl)sulfanyl]-1,2,4-triazin-3-yl]spiro[1,3-dihydroindene-2,4'-piperidine]-1-amine

PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC50 value of 21 nM

ChemicalCAS2498597-94-5MW439.96FormulaC21H22ClN7S
CAS number
2498597-94-5
Molecular weight
439.96
Formula
C21H22ClN7S
Solubility
DMSO ： 100 mg/mL (227·29 mM; Need ultrasonic)
InChIKey
HZCJDRDHKWNUGN-GOSISDBHSA-N
Catalogue number
GC73482
Brand
GLPBIO
Computed properties PubChem CID 155164064 · XLogP 2.5 · TPSA 132 Ų · H-bond donors 2
XLogP
2.5
TPSA
132 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
3
Heavy atoms
30

SMILES C1CN(CCC12CC3=CC=CC=C3[C@H]2N)C4=NC=C(N=N4)SC5=C(C(=NC=C5)N)Cl

Computed descriptors from PubChem (CID 155164064), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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