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Chemical structure of PF-07265807

GC73128

PF-07265807

Also known as N-[3-fluoro-4-[[3-[[(2R)-1-hydroxypropan-2-yl]amino]-1H-pyrazolo[3,4-b]pyridin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide

PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6·1 nM, 13·2 nM and 21·6 nM for AXL, MER and TYRO3, respectively

ChemicalCAS2412356-57-9MW591.57FormulaC29H27F2N7O5
CAS number
2412356-57-9
Molecular weight
591.57
Formula
C29H27F2N7O5
Solubility
DMSO ： 200 mg/mL (338·08 mM; Need ultrasonic)
InChIKey
ILVXQVHFMCJXTE-MRXNPFEDSA-N
Catalogue number
GC73128
Brand
GLPBIO
Computed properties PubChem CID 146425949 · XLogP 3.5 · TPSA 153 Ų · H-bond donors 4
XLogP
3.5
TPSA
153 Ų
H-bond donors
4
H-bond acceptors
10
Rotatable bonds
9
Heavy atoms
43

SMILES C[C@H](CO)NC1=NNC2=NC=CC(=C21)OC3=C(C=C(C=C3)NC(=O)C4=CN(C(=O)N(C4=O)C5=CC=C(C=C5)F)C(C)C)F

Computed descriptors from PubChem (CID 146425949), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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