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Chemical structure of Nampt degrader-2

GC73389

Nampt degrader-2

Also known as N'-[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]-N-[3-oxo-4-propyl-2-[4-(pyridin-3-ylmethylcarbamoyl)phenyl]quinoxalin-6-yl]dodecanediamide

Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41·9 nM

ChemicalCAS3035008-40-0MW1052.33FormulaC59H73N9O7S
CAS number
3035008-40-0
Molecular weight
1052.33
Formula
C59H73N9O7S
Solubility
DMSO ： 100 mg/mL (95·03 mM; Need ultrasonic)
InChIKey
MLJZDBCOWWJHEE-LPLKMGJNSA-N
Catalogue number
GC73389
Brand
GLPBIO
Computed properties PubChem CID 165437867 · XLogP 8.6 · TPSA 244 Ų · H-bond donors 5
XLogP
8.6
TPSA
244 Ų
H-bond donors
5
H-bond acceptors
11
Rotatable bonds
25
Heavy atoms
76

SMILES CCCN1C2=C(C=CC(=C2)NC(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@@H](C[C@H]3C(=O)N[C@@H](C)C4=CC=C(C=C4)C5=C(N=CS5)C)O)C(C)(C)C)N=C(C1=O)C6=CC=C(C=C6)C(=O)NCC7=CN=CC=C7

Computed descriptors from PubChem (CID 165437867), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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