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Chemical structure of Nampt-IN-5

GC62476

Nampt-IN-5

Also known as N-[4-[(2-ethoxybenzimidazol-1-yl)methyl]phenyl]-3-pyridin-3-ylazetidine-1-carboxamide

Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor· Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC50s of 0·7 nM and 3·9 nM against A2780 and COR-L23, respectively

ChemicalCAS2380013-17-0MW427.5FormulaC25H25N5O2
CAS number
2380013-17-0
Molecular weight
427.5
Formula
C25H25N5O2
Solubility
DMSO ： 50 mg/mL (116·96 mM; Need ultrasonic)
InChIKey
JWEBCHOGBDMGBY-UHFFFAOYSA-N
Catalogue number
GC62476
Brand
GLPBIO
Computed properties PubChem CID 146014464 · XLogP 3.3 · TPSA 72.3 Ų · H-bond donors 1
XLogP
3.3
TPSA
72.3 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
32

SMILES CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5

Computed descriptors from PubChem (CID 146014464), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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