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Chemical structure of VHL Ligand 14

GC73330

VHL Ligand 14

Also known as (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM

ChemicalCAS2010986-87-3MW486.63FormulaC25H34N4O4S
CAS number
2010986-87-3
Molecular weight
486.63
Formula
C25H34N4O4S
Solubility
DMSO ： ≥ 100 mg/mL (205·49 mM)
InChIKey
JAHUHEDUDMTTTF-COWZOJLOSA-N
Catalogue number
GC73330
Brand
GLPBIO
Computed properties PubChem CID 122529139 · XLogP 2.7 · TPSA 140 Ų · H-bond donors 3
XLogP
2.7
TPSA
140 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
34

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C)O

Computed descriptors from PubChem (CID 122529139), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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