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Chemical structure of H3B-968

GC73280

H3B-968

Also known as N-(4-ethylphenyl)-2-[[4-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylamino]acetamide

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM), which acts function as helicase, ATPase, and exonuclease

ChemicalCAS2912294-90-5MW548.46FormulaC22H18F6N4O4S
CAS number
2912294-90-5
Molecular weight
548.46
Formula
C22H18F6N4O4S
Solubility
DMSO ： ≥ 250 mg/mL (455·82 mM)
InChIKey
ZLHLWRSVYPZIFD-UHFFFAOYSA-N
Catalogue number
GC73280
Brand
GLPBIO
Computed properties PubChem CID 168476124 · XLogP 5 · TPSA 119 Ų · H-bond donors 2
XLogP
5
TPSA
119 Ų
H-bond donors
2
H-bond acceptors
13
Rotatable bonds
8
Heavy atoms
37

SMILES CCC1=CC=C(C=C1)NC(=O)CNS(=O)(=O)C2=NC(=CC(=N2)C(F)(F)F)C3=CC=C(C=C3)OC(F)(F)F

Computed descriptors from PubChem (CID 168476124), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.