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Chemical structure of H3B-6527

GC19187

H3B-6527

Also known as N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide

H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice

ChemicalCAS1702259-66-2MW629.54FormulaC29H34Cl2N8O4
CAS number
1702259-66-2
Molecular weight
629.54
Formula
C29H34Cl2N8O4
Solubility
DMSO ： 4·6 mg/mL (7·31 mM)
InChIKey
MBWRLLRCTIYXDW-UHFFFAOYSA-N
Catalogue number
GC19187
Brand
GLPBIO
Computed properties PubChem CID 118029202 · XLogP 4.4 · TPSA 124 Ų · H-bond donors 3
XLogP
4.4
TPSA
124 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
10
Heavy atoms
43

SMILES CCN1CCN(CC1)C2=CC(=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl)NC(=O)C=C

Computed descriptors from PubChem (CID 118029202), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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