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Chemical structure of LC-MB12

GC73276

LC-MB12

Also known as 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-[4-[1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperidine-4-carbonyl]piperazin-1-yl]anilino]pyrimidin-4-yl]-1-methylurea

LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11·8 nM

ChemicalCAS2828438-38-4MW899.78FormulaC43H44Cl2N10O8
CAS number
2828438-38-4
Molecular weight
899.78
Formula
C43H44Cl2N10O8
Solubility
DMSO ： 130 mg/mL (144·48 mM; ultrasonic and warming and heat to 60°C)
InChIKey
BUEXWHUMUYQITQ-UHFFFAOYSA-N
Catalogue number
GC73276
Brand
GLPBIO
Computed properties PubChem CID 168432120 · XLogP 4.2 · TPSA 199 Ų · H-bond donors 3
XLogP
4.2
TPSA
199 Ų
H-bond donors
3
H-bond acceptors
13
Rotatable bonds
10
Heavy atoms
63

SMILES CN(C1=NC=NC(=C1)NC2=CC=C(C=C2)N3CCN(CC3)C(=O)C4CCN(CC4)C5=CC6=C(C=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O)C(=O)NC8=C(C(=CC(=C8Cl)OC)OC)Cl

Computed descriptors from PubChem (CID 168432120), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.