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Chemical structure of LC-2

GC61766

LC-2

Also known as (2S,4R)-1-[(2S)-2-[3-[3-[(2S)-2-[[7-(8-chloronaphthalen-1-yl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoroprop-2-enoyl)piperazin-1-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]oxymethyl]pyrrolidin-1-yl]propoxy]propanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0·25 and 0·76 μM· LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines

ChemicalCAS2502156-03-6MW1132.78FormulaC59H71ClFN11O7S
CAS number
2502156-03-6
Molecular weight
1132.78
Formula
C59H71ClFN11O7S
Solubility
DMSO： 50 mg/mL (44·14 mM; ultrasonic and warming and heat to 80°C)
InChIKey
ZCGQZLKPUVGCBQ-HLMPTVQRSA-N
Catalogue number
GC61766
Brand
GLPBIO
Computed properties PubChem CID 154727765 · XLogP 7.3 · TPSA 238 Ų · H-bond donors 3
XLogP
7.3
TPSA
238 Ų
H-bond donors
3
H-bond acceptors
16
Rotatable bonds
21
Heavy atoms
80

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCOCCCN4CCC[C@H]4COC5=NC6=C(CCN(C6)C7=CC=CC8=C7C(=CC=C8)Cl)C(=N5)N9CCN([C@H](C9)CC#N)C(=O)C(=C)F)O

Computed descriptors from PubChem (CID 154727765), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.