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Chemical structure of KTX-951

GC73161

KTX-951

Also known as 6-(1,1-difluoroethyl)-N-[2-[4-[[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]-7-azaspiro[3.5]nonan-7-yl]methyl]cyclohexyl]-6-methoxyindazol-5-yl]pyridine-2-carboxamide

KTX-951 is a PROTAC targeting IRAK4 degradation (DC50=18 nM)

ChemicalCAS2573298-36-7MW850.95FormulaC46H52F2N8O6
CAS number
2573298-36-7
Molecular weight
850.95
Formula
C46H52F2N8O6
Solubility
DMSO ： 50 mg/mL (58·76 mM; Need ultrasonic)
InChIKey
XMUGELSEEJWFAK-UHFFFAOYSA-N
Catalogue number
GC73161
Brand
GLPBIO
Computed properties PubChem CID 155437705 · XLogP 6.5 · TPSA 168 Ų · H-bond donors 3
XLogP
6.5
TPSA
168 Ų
H-bond donors
3
H-bond acceptors
12
Rotatable bonds
12
Heavy atoms
62

SMILES CC(C1=CC=CC(=N1)C(=O)NC2=CC3=CN(N=C3C=C2OC)C4CCC(CC4)CN5CCC6(CC5)CC(C6)CCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O)(F)F

Computed descriptors from PubChem (CID 155437705), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.