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Chemical structure of KTX-582

GC73159

KTX-582

Also known as N-[2-[4-[[3-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]cyclobutyl]oxypropyl-methylamino]methyl]cyclohexyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide

KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively

ChemicalCAS2573298-13-0MW872.93FormulaC45H51F3N8O7
CAS number
2573298-13-0
Molecular weight
872.93
Formula
C45H51F3N8O7
Solubility
DMSO ： 100 mg/mL (114·56 mM; Need ultrasonic)
InChIKey
CKFOAVDINFHZIR-UHFFFAOYSA-N
Catalogue number
GC73159
Brand
GLPBIO
Computed properties PubChem CID 165437238 · XLogP 5 · TPSA 188 Ų · H-bond donors 4
XLogP
5
TPSA
188 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
14
Heavy atoms
63

SMILES CC(C)(C1=CC2=NN(C=C2C=C1NC(=O)C3=NC(=CC=C3)C(F)(F)F)C4CCC(CC4)CN(C)CCCOC5CC(C5)NC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)O

Computed descriptors from PubChem (CID 165437238), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.