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Chemical structure of DB18

GC73007

DB18

Also known as N-(3-chlorophenyl)-8-[[1-(4-methyl-2-nitrophenyl)triazol-4-yl]methoxy]quinazolin-2-amine

DB18 is a potent and selective inhibitor of CDC2-like kinases (CLKs), with IC50 values in the range of 10-30 nM for CLK1, CLK2 and CLK4

ChemicalCAS2587177-94-2MW487.9FormulaC24H18ClN7O3
CAS number
2587177-94-2
Molecular weight
487.9
Formula
C24H18ClN7O3
Solubility
DMSO ： 50 mg/mL (102·48 mM; ultrasonic and warming and heat to 60°C)
InChIKey
JEPGNFQKCRZPHJ-UHFFFAOYSA-N
Catalogue number
GC73007
Brand
GLPBIO
Computed properties PubChem CID 162666194 · XLogP 5.2 · TPSA 124 Ų · H-bond donors 1
XLogP
5.2
TPSA
124 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
35

SMILES CC1=CC(=C(C=C1)N2C=C(N=N2)COC3=CC=CC4=CN=C(N=C43)NC5=CC(=CC=C5)Cl)[N+](=O)[O-]

Computed descriptors from PubChem (CID 162666194), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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