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Chemical structure of PROTAC TYK2 degradation agent1

GC71201

PROTAC TYK2 degradation agent1

Also known as 6-[[5-[[10-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-10-oxodecyl]carbamoyl]-2-pyridinyl]amino]-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-methylpyridine-3-carboxamide

PROTAC TYK2 degradation agent1 is a potent and subtype-selective TYK2 degrader

ChemicalCAS2921556-14-9MW1056.28FormulaC55H69N13O7S
CAS number
2921556-14-9
Molecular weight
1056.28
Formula
C55H69N13O7S
Solubility
DMSO ： 10 mg/mL (9·47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
ZQBPERKIXUCCNQ-DXGZDBETSA-N
Catalogue number
GC71201
Brand
GLPBIO
Computed properties PubChem CID 166642572 · XLogP 7.6 · TPSA 288 Ų · H-bond donors 7
XLogP
7.6
TPSA
288 Ų
H-bond donors
7
H-bond acceptors
15
Rotatable bonds
25
Heavy atoms
76

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCNC(=O)C4=CN=C(C=C4)NC5=NC=C(C(=C5)NC6=CC=CC(=C6OC)C7=NN(C=N7)C)C(=O)NC)O

Computed descriptors from PubChem (CID 166642572), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.