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Chemical structure of DN-1289

GC71195

DN-1289

Also known as 3-(difluoromethoxy)-5-[6-(3,3-difluoropyrrolidin-1-yl)-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrimidin-4-yl]pyrazin-2-amine

DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM)

ChemicalCAS3026597-15-6MW441.38FormulaC18H19F4N7O2
CAS number
3026597-15-6
Molecular weight
441.38
Formula
C18H19F4N7O2
InChIKey
AVWDJSXSWJBVBP-UWVGGRQHSA-N
Catalogue number
GC71195
Brand
GLPBIO
Computed properties PubChem CID 167312371 · XLogP 2.3 · TPSA 103 Ų · H-bond donors 1
XLogP
2.3
TPSA
103 Ų
H-bond donors
1
H-bond acceptors
13
Rotatable bonds
5
Heavy atoms
31

SMILES C1CN(CC1(F)F)C2=NC(=NC(=C2)C3=CN=C(C(=N3)OC(F)F)N)N4C[C@@H]5C[C@H]4CO5

Computed descriptors from PubChem (CID 167312371), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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