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Chemical structure of MS8511

GC71130

MS8511

Also known as N-[6-methoxy-4-[(1-propan-2-ylpiperidin-4-yl)amino]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-2-yl]prop-2-enamide

MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM (G9a) and 140 nM (GLP), and Kd values of 44 nM (G9a) and 46 nM (GLP)

ChemicalCAS2866408-21-9MW495.66FormulaC28H41N5O3
CAS number
2866408-21-9
Molecular weight
495.66
Formula
C28H41N5O3
Solubility
DMSO ： 100 mg/mL (201·75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
FNRUPVONTWZCGL-UHFFFAOYSA-N
Catalogue number
GC71130
Brand
GLPBIO
Computed properties PubChem CID 164512403 · XLogP 4.5 · TPSA 79 Ų · H-bond donors 2
XLogP
4.5
TPSA
79 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
36

SMILES CC(C)N1CCC(CC1)NC2=CC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)NC(=O)C=C

Computed descriptors from PubChem (CID 164512403), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.