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Chemical structure of DNL343

GC71091

DNL343

Also known as 2-(4-chlorophenoxy)-N-[3-[5-[3-(trifluoromethoxy)cyclobutyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]acetamide

DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR)

ChemicalCAS2278265-85-1MW457.83FormulaC20H19ClF3N3O4
CAS number
2278265-85-1
Molecular weight
457.83
Formula
C20H19ClF3N3O4
Solubility
DMSO ： 100 mg/mL (218·42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
IKPNRMYDOSNVAU-UHFFFAOYSA-N
Catalogue number
GC71091
Brand
GLPBIO
Computed properties PubChem CID 137491382 · XLogP 3.7 · TPSA 86.5 Ų · H-bond donors 1
XLogP
3.7
TPSA
86.5 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
31

SMILES C1C(CC1OC(F)(F)F)C2=NN=C(O2)C34CC(C3)(C4)NC(=O)COC5=CC=C(C=C5)Cl

Computed descriptors from PubChem (CID 137491382), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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