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Chemical structure of JNJ-41443532

GC70720

JNJ-41443532

Also known as N-[2-[[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide

JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM)

ChemicalCAS1228650-83-6MW482.52FormulaC22H25F3N4O3S
CAS number
1228650-83-6
Molecular weight
482.52
Formula
C22H25F3N4O3S
Solubility
DMSO ： 100 mg/mL (207·25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
CFKBNYUHQSQBSX-UHFFFAOYSA-N
Catalogue number
GC70720
Brand
GLPBIO
Computed properties PubChem CID 46208367 · XLogP 2.3 · TPSA 123 Ų · H-bond donors 3
XLogP
2.3
TPSA
123 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
33

SMILES C1CC(CCC1N2CC(C2)NC(=O)CNC(=O)C3=CC(=CC=C3)C(F)(F)F)(C4=CN=CS4)O

Computed descriptors from PubChem (CID 46208367), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.