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Chemical structure of JNJ-1013

GC69316

JNJ-1013

Also known as N-[4-[4-[2-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]piperidin-1-yl]-2-methoxyphenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide

JNJ-1013 is an effective selective IRAK1 degrader, with IC50 values of 72, 443, and 1071 nM for IRAK1, IRAK4, and VHL FP respectively· JNJ-1013 induces apoptosis and increases the expression of cleaved PARP· JNJ-1013 reduces the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705)

ChemicalCAS2597343-08-1MW878.05FormulaC46H55N9O7S
CAS number
2597343-08-1
Molecular weight
878.05
Formula
C46H55N9O7S
Solubility
DMSO ： 25 mg/mL (28·47 mM; ultrasonic and warming and heat to 60°C)
InChIKey
MHRNVFQJUUXQIG-VIFUUBRESA-N
Catalogue number
GC69316
Brand
GLPBIO
Computed properties PubChem CID 162660665 · XLogP 5 · TPSA 232 Ų · H-bond donors 5
XLogP
5
TPSA
232 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
15
Heavy atoms
63

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COC4CCN(CC4)C5=CC(=C(C=C5)NC(=O)C6=CC=CC(=N6)C7=CC=NN7)OC)O

Computed descriptors from PubChem (CID 162660665), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.