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Chemical structure of AMPA receptor modulator-1

GC70348

AMPA receptor modulator-1

Also known as 5-[2-chloro-6-(trifluoromethoxy)phenyl]-7-methyl-1,3-dihydroindol-2-one

AMPA receptor modulator-1 is a potent, orally active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC50 of 9·7, more selective over GluA1/γ-2 (pIC50=5)

ChemicalCAS2036074-41-4MW341.71FormulaC16H11ClF3NO2
CAS number
2036074-41-4
Molecular weight
341.71
Formula
C16H11ClF3NO2
InChIKey
AYAICAKEBFTALD-UHFFFAOYSA-N
Catalogue number
GC70348
Brand
GLPBIO
Computed properties PubChem CID 122655505 · XLogP 4.6 · TPSA 38.3 Ų · H-bond donors 1
XLogP
4.6
TPSA
38.3 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
23

SMILES CC1=CC(=CC2=C1NC(=O)C2)C3=C(C=CC=C3Cl)OC(F)(F)F

Computed descriptors from PubChem (CID 122655505), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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