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Chemical structure of YX-2-107

GC70162

YX-2-107

Also known as N-[4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]piperazin-1-yl]-2-oxoethyl]amino]butyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide

YX-2-107 is a selective degrader of CDK6 using PROTAC technology (IC50= 4·4 nM)· In vitro, YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression, and suppresses the development of Ph+ ALL in rats· YX-2-107 can be used for research on Ph chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL)

ChemicalCAS2417408-46-7MW889.95FormulaC45H51N11O9
CAS number
2417408-46-7
Molecular weight
889.95
Formula
C45H51N11O9
Solubility
DMSO ： 150 mg/mL (168·55 mM; ultrasonic and warming and heat to 60°C)
InChIKey
JNYCZFGLJGFFEL-UHFFFAOYSA-N
Catalogue number
GC70162
Brand
GLPBIO
Computed properties PubChem CID 166642460 · XLogP 1.3 · TPSA 246 Ų · H-bond donors 4
XLogP
1.3
TPSA
246 Ų
H-bond donors
4
H-bond acceptors
15
Rotatable bonds
16
Heavy atoms
65

SMILES CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)CNCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C

Computed descriptors from PubChem (CID 166642460), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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