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Chemical structure of YZ129

GC66059

YZ129

Also known as 4-(isoquinolin-6-ylamino)naphthalene-1,2-dione

YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation· YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration

ChemicalCAS1643120-60-8MW300.31FormulaC19H12N2O2
CAS number
1643120-60-8
Molecular weight
300.31
Formula
C19H12N2O2
Solubility
DMSO ： 5·6 mg/mL (18·65 mM; ultrasonic and warming and heat to 80°C)
InChIKey
NYDMVPHEEBVAHT-UHFFFAOYSA-N
Catalogue number
GC66059
Brand
GLPBIO
Computed properties PubChem CID 137628683 · XLogP 2.9 · TPSA 59.1 Ų · H-bond donors 1
XLogP
2.9
TPSA
59.1 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
23

SMILES C1=CC=C2C(=C1)C(=CC(=O)C2=O)NC3=CC4=C(C=C3)C=NC=C4

Computed descriptors from PubChem (CID 137628683), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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