Loading...
Chemical structure of SRI-42127

GC69943

SRI-42127

Also known as 3-(1H-indazol-6-yl)-N-methyl-N-(oxan-4-yl)imidazo[1,2-b]pyridazin-6-amine

SRI-42127 is a HuR translocation inhibitor· HuR is an RNA regulatory factor that binds to ARE elements, and HuR translocation can promote the production of inflammatory cytokines in glial cells· SRI-42127 can disrupt mRNA stability and inhibit gene promoter activation· SRI-42127 also inhibits microglial activation, reducing the recruitment/chemotaxis of neutrophils and monocytes

ChemicalCAS2727872-68-4MW348.4FormulaC19H20N6O
CAS number
2727872-68-4
Molecular weight
348.4
Formula
C19H20N6O
Solubility
DMSO ： 50 mg/mL (143·51 mM; ultrasonic and warming and heat to 60°C)
InChIKey
AEHZEVSNZUVPNR-UHFFFAOYSA-N
Catalogue number
GC69943
Brand
GLPBIO
Computed properties PubChem CID 163415849 · XLogP 2.5 · TPSA 71.3 Ų · H-bond donors 1
XLogP
2.5
TPSA
71.3 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
26

SMILES CN(C1CCOCC1)C2=NN3C(=NC=C3C4=CC5=C(C=C4)C=NN5)C=C2

Computed descriptors from PubChem (CID 163415849), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.