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Chemical structure of SRI-41315

GC69942

SRI-41315

Also known as 2-cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5-dione

SRI-41315 induces long pauses at termination codons, inhibits premature termination codons (PTCs) associated with permanent and primary human bronchial epithelial cell cystic fibrosis, restores the expression and function of CFTR (cystic fibrosis transmembrane conductance regulator)· SRI-41315 inhibits PTCs by reducing the abundance of the termination factor eRF1· SRI-41315 also enhances aminoglycoside-mediated readthrough, resulting in synergistic increases in CFTR activity

ChemicalCAS1613509-49-1MW357.41FormulaC22H19N3O2
CAS number
1613509-49-1
Molecular weight
357.41
Formula
C22H19N3O2
Solubility
DMSO ： 20·83 mg/mL (58·28 mM; Need ultrasonic)
InChIKey
XUOTZAUZHWCGHL-UHFFFAOYSA-N
Catalogue number
GC69942
Brand
GLPBIO
Computed properties PubChem CID 76283898 · XLogP 3.6 · TPSA 53 Ų · H-bond donors 0
XLogP
3.6
TPSA
53 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
27

SMILES CN1C2=CC=CC=C2C(=O)C3=C1N=C(N(C3=O)C4=CC=CC=C4)C5CCC5

Computed descriptors from PubChem (CID 76283898), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.