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Chemical structure of Rohinitib

GC69827

Rohinitib

Also known as (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide

Rohinitib is an effective and specific inhibitor of eIF4A· Rohinitib induces apoptosis in acute myeloid leukemia (AML) cell lines and reduces the leukemia burden in AML xenograft mouse models· Rohinitib can be used for research on AML

ChemicalCAS1139253-73-8MW521.56FormulaC29H31NO8
CAS number
1139253-73-8
Molecular weight
521.56
Formula
C29H31NO8
Solubility
DMSO ： 200 mg/mL (383·46 mM; Need ultrasonic)
InChIKey
TZDAVNWDKGYBCW-IDAMAFBJSA-N
Catalogue number
GC69827
Brand
GLPBIO
Computed properties PubChem CID 49793307 · XLogP 2.9 · TPSA 107 Ų · H-bond donors 2
XLogP
2.9
TPSA
107 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
38

SMILES CN(C(=O)[C@@H]1[C@H]([C@]2([C@@]([C@@H]1O)(C3=C(O2)C=C(C=C3OC)OC)O)C4=CC=C(C=C4)OC)C5=CC=CC=C5)OC

Computed descriptors from PubChem (CID 49793307), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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