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Chemical structure of POLA1 inhibitor 1

GC69721

POLA1 inhibitor 1

Also known as (E)-3-[4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-[(E)-hydroxyiminomethyl]phenyl]prop-2-enoic acid

POLA1 inhibitor 1 (Compound 12) is an orally active inhibitor of POLA1· It exhibits anti-tumor activity against several types of tumor tissues and Adaroten-resistant cell lines

ChemicalCAS2217671-41-3MW417.5FormulaC26H27NO4
CAS number
2217671-41-3
Molecular weight
417.5
Formula
C26H27NO4
Solubility
DMSO ： 180 mg/mL (431·14 mM; Need ultrasonic)
InChIKey
PLQNJDDLZLIMNK-DTHWQZMASA-N
Catalogue number
GC69721
Brand
GLPBIO
Computed properties PubChem CID 164517069 · XLogP 6.3 · TPSA 90.1 Ų · H-bond donors 3
XLogP
6.3
TPSA
90.1 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
31

SMILES C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=C(C=C(C=C5)/C=C/C(=O)O)/C=N/O)O

Computed descriptors from PubChem (CID 164517069), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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