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Chemical structure of POB

GB40328

POB

Also known as methyl (2S)-2-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methylamino]-5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate

POB (946135-39-3) is a transition state-based, cell permeable pro-drug inhibitor of ODC, a key enzyme involved in polyamine synthesis and a potential cancer drug target· Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed· This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation· POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme· More potent than DFMO

ChemicalCAS946135-39-3MW397.47FormulaC19H31N3O6
CAS number
946135-39-3
Molecular weight
397.47
Formula
C19H31N3O6
InChIKey
NSVJNNHNIQICDC-HNNXBMFYSA-N
Catalogue number
GB40328
Brand
GLPBIO
Computed properties PubChem CID 177675336 · XLogP 1.3 · TPSA 130 Ų · H-bond donors 4
XLogP
1.3
TPSA
130 Ų
H-bond donors
4
H-bond acceptors
8
Rotatable bonds
12
Heavy atoms
28

SMILES CC1=NC=C(C(=C1O)CN[C@@H](CCCNC(=O)OC(C)(C)C)C(=O)OC)CO

Computed descriptors from PubChem (CID 177675336), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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