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Chemical structure of Plogosertib

GC69718

Plogosertib

Also known as 4-[(9-cyclopentyl-5-methyl-6-oxospiro[8H-pyrimido[4,5-b][1,4]diazepine-7,1'-cyclopropane]-2-yl)amino]-3-methoxy-N-[4-(4-methylpiperazin-1-yl)cyclohexyl]benzamide

Plogosertib (CYC140) is a selective, potent, orally active ATP-competitive PLK1 inhibitor (IC50: 3 nM)· Plogosertib is an anti-cancer agent with anti-proliferative activity and can be used for research on various tumors including esophageal cancer, gastric cancer, leukemia, non-small cell lung cancer, ovarian cancer and squamous cell carcinoma

ChemicalCAS1137212-79-3MW616.8FormulaC34H48N8O3
CAS number
1137212-79-3
Molecular weight
616.8
Formula
C34H48N8O3
Solubility
DMSO ： 100 mg/mL (162·13 mM; Need ultrasonic)
InChIKey
UFNLNMWVOMFWGS-UHFFFAOYSA-N
Catalogue number
GC69718
Brand
GLPBIO
Computed properties PubChem CID 42640739 · XLogP 3.6 · TPSA 106 Ų · H-bond donors 2
XLogP
3.6
TPSA
106 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
45

SMILES CN1CCN(CC1)C2CCC(CC2)NC(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(CC6(CC6)C(=O)N5C)C7CCCC7)OC

Computed descriptors from PubChem (CID 42640739), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.