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Chemical structure of PI3K/mTOR Inhibitor-11

GC69709

PI3K/mTOR Inhibitor-11

Also known as 2-methyl-2-[5-[2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-5-yl)imidazo[4,5-c]quinolin-1-yl]-2-pyridinyl]propanenitrile

PI3K/mTOR Inhibitor-11 is an orally active inhibitor of PI3K/mTOR (with IC50 values of 3·5, 4·6, and 21·3 nM for PI3Kα, PI3Kδ, and mTOR, respectively)· It regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 protein· PI3K/mTOR Inhibitor-11 can be used in cancer research

ChemicalCAS2845104-25-6MW443.5FormulaC27H21N7
CAS number
2845104-25-6
Molecular weight
443.5
Formula
C27H21N7
Solubility
DMSO ： 40 mg/mL (90·19 mM; ultrasonic and warming and heat to 60°C)
InChIKey
JDUUUKXVZOZLSS-UHFFFAOYSA-N
Catalogue number
GC69709
Brand
GLPBIO
Computed properties PubChem CID 168295564 · XLogP 4.3 · TPSA 96.1 Ų · H-bond donors 1
XLogP
4.3
TPSA
96.1 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
34

SMILES CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CN=C(C=C4)C(C)(C)C#N)C5=CN=C6C(=C5)C=CN6

Computed descriptors from PubChem (CID 168295564), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.