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Chemical structure of Nrf2 activator-2

GC69590

Nrf2 activator-2

Also known as 6-bromo-8,8-dimethyl-3-phenyl-9,10-dihydropyrano[2,3-h]chromen-2-one

Nrf2 activator-2 (compound O15) is a derivative of sulforaphane, an effective Nrf2 activator with an EC50 of 2·9 μM in 293 T cells· Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thereby showing an activating effect on Nrf2· Nrf2 activator-2 significantly reduces the level of ubiquitinated Nrf2 in cells

ChemicalCAS2770448-53-6MW385.25FormulaC20H17BrO3
CAS number
2770448-53-6
Molecular weight
385.25
Formula
C20H17BrO3
InChIKey
AWBUMGZRUKQFIN-UHFFFAOYSA-N
Catalogue number
GC69590
Brand
GLPBIO
Computed properties PubChem CID 163322319 · XLogP 5.2 · TPSA 35.5 Ų · H-bond donors 0
XLogP
5.2
TPSA
35.5 Ų
H-bond donors
0
H-bond acceptors
3
Rotatable bonds
1
Heavy atoms
24

SMILES CC1(CCC2=C3C(=CC(=C2O1)Br)C=C(C(=O)O3)C4=CC=CC=C4)C

Computed descriptors from PubChem (CID 163322319), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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