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Chemical structure of MRT-2359

GC69497

MRT-2359

Also known as [2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]methyl N-[2-fluoro-5-(trifluoromethoxy)phenyl]carbamate

MRT-2359 is an orally effective GSPT1 degrader with anti-tumor activity· It also inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells· MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDX)

ChemicalCAS2803881-11-8MW495.38FormulaC22H17F4N3O6
CAS number
2803881-11-8
Molecular weight
495.38
Formula
C22H17F4N3O6
Solubility
DMSO ： 100 mg/mL (201·87 mM; Need ultrasonic)
InChIKey
HNTGMIGBGVFOBT-UHFFFAOYSA-N
Catalogue number
GC69497
Brand
GLPBIO
Computed properties PubChem CID 164584214 · XLogP 2.5 · TPSA 114 Ų · H-bond donors 2
XLogP
2.5
TPSA
114 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
35

SMILES C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=C(C=C3)COC(=O)NC4=C(C=CC(=C4)OC(F)(F)F)F

Computed descriptors from PubChem (CID 164584214), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.