Loading...
Chemical structure of MRL-871

GC69496

MRL-871

Also known as 4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]indazol-3-yl]benzoic acid

MRL-871 (compound 3) is an effective inverse agonist of retinoic acid receptor-related orphan receptor gamma t (RORγt), with an IC50 of 264 nM· MRL-871 has a unique imidazole chemical structure and can effectively reduce the generation of IL-17a mRNA in EL4 cells

ChemicalCAS1392809-08-3MW444.79FormulaC22H12ClF3N2O3
CAS number
1392809-08-3
Molecular weight
444.79
Formula
C22H12ClF3N2O3
Solubility
DMSO ： 25 mg/mL (56·21 mM; ultrasonic and warming and heat to 60°C)
InChIKey
DANLZOIRUUHIIX-UHFFFAOYSA-N
Catalogue number
GC69496
Brand
GLPBIO
Computed properties PubChem CID 68159303 · XLogP 5.8 · TPSA 72.2 Ų · H-bond donors 1
XLogP
5.8
TPSA
72.2 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
31

SMILES C1=CC=C2C(=C1)C(=NN2C(=O)C3=C(C=CC=C3Cl)C(F)(F)F)C4=CC=C(C=C4)C(=O)O

Computed descriptors from PubChem (CID 68159303), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.