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Chemical structure of MRK-898

GC69495

MRK-898

Also known as 5-fluoro-2-[2-fluoro-5-[7-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-yl]phenyl]benzonitrile

MRK-898 is an orally effective GABA(A) receptor modulator· MRK-898 binds to the α1, α2, α3 and α5 subunits of the GABA receptor with Ki values of 1·2 nM, 1·0 nM, 0·73 nM and 0·50 nM respectively· However, GABA(A) receptors containing the α1 subunit have been identified as “sedative“ receptors while those containing the α2 and/or α3 subunits have been identified as “anxiolytic“ subtypes

ChemicalCAS461450-30-6MW400.3FormulaC20H9F5N4
CAS number
461450-30-6
Molecular weight
400.3
Formula
C20H9F5N4
Solubility
DMSO ： 100 mg/mL (249·81 mM; Need ultrasonic)
InChIKey
XXRKXVKJMSIZSM-UHFFFAOYSA-N
Catalogue number
GC69495
Brand
GLPBIO
Computed properties PubChem CID 9843909 · XLogP 5.2 · TPSA 54 Ų · H-bond donors 0
XLogP
5.2
TPSA
54 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
2
Heavy atoms
29

SMILES C1=CC(=C(C=C1C2=CN=C3N2C=CC(=N3)C(F)(F)F)C4=C(C=C(C=C4)F)C#N)F

Computed descriptors from PubChem (CID 9843909), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.