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Chemical structure of JNJ-61803534

GC69318

JNJ-61803534

Also known as 5-[2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[(2R)-2-methylpyrrolidine-1-carbonyl]-1,3-thiazole-2-carboxamide

JNJ-61803534 is an effective and orally active RORγt inverse agonist with an IC50 of 9·6 nM· It has anti-inflammatory activity and inhibits the production of IL-17A in human CD4+ T cells under Th17 differentiation conditions

ChemicalCAS1917306-14-9MW622.41FormulaC23H23Cl2F6N3O4S
CAS number
1917306-14-9
Molecular weight
622.41
Formula
C23H23Cl2F6N3O4S
Solubility
DMSO ： 300 mg/mL (482·00 mM; Need ultrasonic)
InChIKey
ZQHVEGQHOKDZEN-SNVBAGLBSA-N
Catalogue number
GC69318
Brand
GLPBIO
Computed properties PubChem CID 121303394 · XLogP 5.3 · TPSA 131 Ų · H-bond donors 3
XLogP
5.3
TPSA
131 Ų
H-bond donors
3
H-bond acceptors
12
Rotatable bonds
6
Heavy atoms
39

SMILES C[C@@H]1CCCN1C(=O)C2=C(SC(=N2)C(=O)NCC(C)(C)O)C3=C(C(=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)Cl)Cl

Computed descriptors from PubChem (CID 121303394), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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