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Chemical structure of JNJ-28583113

GC69317

JNJ-28583113

Also known as ethyl 2-[3-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro-4H-cyclohepta[d]pyrazol-1-yl]acetate

JNJ-28583113 is a brain-penetrant TRPM2 antagonist· It inhibits the phosphorylation of GSK3α and β subunits by blocking TRPM2· JNJ-28583113 protects cells from oxidative stress-induced cell death· It also inhibits the release of cytokines from microglia in response to pro-inflammatory stimuli

ChemicalCAS2765255-93-2MW366.38FormulaC19H21F3N2O2
CAS number
2765255-93-2
Molecular weight
366.38
Formula
C19H21F3N2O2
Solubility
DMSO ： 100 mg/mL (272·94 mM; Need ultrasonic)
InChIKey
WOERTJPEDOUEDS-UHFFFAOYSA-N
Catalogue number
GC69317
Brand
GLPBIO
Computed properties PubChem CID 164628567 · XLogP 4.9 · TPSA 44.1 Ų · H-bond donors 0
XLogP
4.9
TPSA
44.1 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
26

SMILES CCOC(=O)CN1C2=C(CCCCC2)C(=N1)C3=CC=C(C=C3)C(F)(F)F

Computed descriptors from PubChem (CID 164628567), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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