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Chemical structure of JAK-IN-25

GC69306

JAK-IN-25

Also known as methyl 6-[1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-4-oxo-5H-pyrazolo[1,5-a]pyrazine-2-carboxylate

JAK-IN-25 (compound 19) is an effective JAK inhibitor with IC50 values of 6 nM, 21 nM, 8 nM, and 1051 nM for TYK2, JAK1, JAK2, and JAK3 respectively· It inhibits human whole blood IL-12 (HEB IL-12) with an IC50 value of 28 nM· JAK-IN-25 has potential for use in cancer research

ChemicalCAS2127110-22-7MW379.37FormulaC19H17N5O4
CAS number
2127110-22-7
Molecular weight
379.37
Formula
C19H17N5O4
Solubility
DMSO ： 5 mg/mL (13·18 mM; ultrasonic and warming and heat to 60°C)
InChIKey
KJSUDTXSTRQSEJ-UHFFFAOYSA-N
Catalogue number
GC69306
Brand
GLPBIO
Computed properties PubChem CID 130339262 · XLogP 1.4 · TPSA 100 Ų · H-bond donors 1
XLogP
1.4
TPSA
100 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
28

SMILES COC1=CC=C(C=C1)CN2C=C(C=N2)C3=CN4C(=CC(=N4)C(=O)OC)C(=O)N3

Computed descriptors from PubChem (CID 130339262), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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