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Chemical structure of INCB13739

GC69274

INCB13739

Also known as N-methyl-5-[4-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]phenyl]pyridine-2-carboxamide

INCB13739 is an orally effective, selective, and tissue-specific inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), with IC50 values of 3·2 nM (for the enzyme) and 1·1 nM (for PBMC)· INCB13739 can be used for research on type 2 diabetes (T2DM) and obesity

ChemicalCAS869974-19-6MW467.52FormulaC28H25N3O4
CAS number
869974-19-6
Molecular weight
467.52
Formula
C28H25N3O4
Solubility
DMSO ： 125 mg/mL (267·37 mM; Need ultrasonic)
InChIKey
BDQCDIWFPIDPQU-NDEPHWFRSA-N
Catalogue number
GC69274
Brand
GLPBIO
Computed properties PubChem CID 66662059 · XLogP 2.9 · TPSA 88.6 Ų · H-bond donors 1
XLogP
2.9
TPSA
88.6 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
35

SMILES CNC(=O)C1=NC=C(C=C1)C2=CC=C(C=C2)C3(CC3)C(=O)N4CC[C@]5(C4)C6=CC=CC=C6C(=O)O5

Computed descriptors from PubChem (CID 66662059), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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