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Chemical structure of INCB28060

GC17866

INCB28060

Also known as 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

INCB28060 (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0·13 nM)· INCB28060 can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5· INCB28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis· Antitumor activity· INCB28060 is largely metabolized by CYP3A4 and aldehyde oxidase

ChemicalCAS1029712-80-8MW412.42FormulaC23H17FN6O
CAS number
1029712-80-8
Molecular weight
412.42
Formula
C23H17FN6O
Solubility
≥ 5·15mg/mL in DMSO with gentle warming
InChIKey
LIOLIMKSCNQPLV-UHFFFAOYSA-N
Catalogue number
GC17866
Brand
GLPBIO
Computed properties PubChem CID 25145656 · XLogP 2.9 · TPSA 85.1 Ų · H-bond donors 1
XLogP
2.9
TPSA
85.1 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
31

SMILES CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F

Computed descriptors from PubChem (CID 25145656), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.