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Chemical structure of GSK3735967

GC69194

GSK3735967

Also known as 2-amino-N-[[4-[[3,5-dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)-2-pyridinyl]sulfanylmethyl]phenyl]methyl]acetamide

GSK3735967 is a selective, reversible, non-nucleoside DNMT1 inhibitor· It contains a planar dicyanopyridine core that can specifically embed into the semi-methylated CpG dinucleotide bound by DNMT1· GSK3735967 has three binding sites, one of which can bind to histone H4K20me3

ChemicalCAS2170136-86-2MW477.62FormulaC25H31N7OS
CAS number
2170136-86-2
Molecular weight
477.62
Formula
C25H31N7OS
Solubility
DMSO ： 31·25 mg/mL (65·43 mM; ultrasonic and warming and heat to 70°C)
InChIKey
QPLFMVVUDGWTPG-UHFFFAOYSA-N
Catalogue number
GC69194
Brand
GLPBIO
Computed properties PubChem CID 132233120 · XLogP 2.3 · TPSA 147 Ų · H-bond donors 2
XLogP
2.3
TPSA
147 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
34

SMILES CCC1=C(C(=NC(=C1C#N)SCC2=CC=C(C=C2)CNC(=O)CN)N3CCCN(CC3)C)C#N

Computed descriptors from PubChem (CID 132233120), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.